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Long-Term Effects Of LSD

Long-Term Effects Of LSD

Giordano Novak

Giordano Novak

Medically reviewed by Giordano Novak, University of São Paulo on April 3rd 2022

Key Takeaways:

  • LSD causes long-term changes in the brain, including a decrease in serotonin receptor density.
  • Acid long-term effects abuse can include flashbacks, personality and mood changes, hallucinations, impaired coordination, increased risk for mental health issues and more.
  • The effects of long-term LSD use can be damaging to physical and psychological health.


LSD is one heck of a drug, and while you might be thinking about experiencing it for yourself, there are good and bad aspects. 

As a powerful hallucinogenic drug, acid has the ability to take you on the ride of a lifetime, but there are potential long-term effects you need to be aware of.

The long-term effects of acid can last a few days or even years. They include the potential to develop HPPD (flashbacks) and serotonin syndrome in addition to comparatively milder effects, such as trouble sleeping and increased levels of anxiety.

There’s a lot more to LSD’s long-term effects, and this article is here to take you through them all. We’ll explore what acid is, how it works, and the ways in which it might impact your brain chemistry.


What Is LSD (Acid)?

Lysergic acid diethylamide (LSD) is a powerful hallucinogenic drug derived from the ergot fungus, which grows NATURALLY on rye and other grains. It’s usually taken orally in liquid or tablet form, though it can also be injected.

The effects of LSD are unpredictable and vary greatly depending on the dose, frequency of use, and the user’s personality. 

It can cause visual and auditory HALLUCINATIONS, altered perception of time and self, mood changes, and more [5].


Pro Tip: LSD is a Schedule I substance in the US, which means it has a high potential for abuse and no accepted medical use.


Carhat-Harris LSD Quote (White)


How Does Acid Work?

LSD works by binding to serotonin receptors in the brain. Serotonin is a neurotransmitter associated with MOOD and behavior regulation, among other things.

When LSD binds to these receptors, it causes a disruption in normal brain activity. This leads to CHANGES in perception, cognition, and mood. 

It also increases levels of dopamine and norepinephrine, two hormones that play a role in feelings of PLEASURE.

The effects of LSD can last up to 12 hours or longer and can be intense and unpredictable. 

You might experience visual or auditory hallucinations as well as changes in your sense of TIME and self. SOME users have reported spiritual awakenings that have changed their life.

Short-term effects of LSD use may include [4]:

  • Intense visual, auditory, and tactile hallucinations
  • Altered senses of time and space
  • Heightened emotions and sensory perceptions
  • Nausea and chills
  • Tremors
  • Loss of appetite
  • Sweating
  • Dilated pupils
  • Difficulty concentrating or focusing on tasks
  • Paranoia and panic attacks


What are the Long-Term Effects of LSD?

The long-term effects of LSD vary, and there is still more research to be done on the topic. 

However, it can be linked to WORSENING several mental health issues, such as anxiety and schizophrenia. This is because of the way it interacts with the brain during use.

It’s also possible to develop HPPD (hallucinogen-persisting perception disorder), which is characterized by PERSISTENT visual and auditory hallucinations [2]. Those with pre-existing mental health conditions are more prone to the development of this effect.


Pro Tip: LSD should never be missed with prescription psychiatric medications used to treat depression or mental illness. Psychadelic drugs should also not be mixed with SSRIs or alcohol.


In rare cases, users can experience serotonin syndrome, which is a SERIOUS condition that can cause confusion, agitation, elevated heart rate and body temperature, seizures, coma, and even death [3].

The symptoms of serotonin syndrome include:

  • Diarrhea
  • Restlessness or agitation
  • Vomiting or nausea
  • Irregular or rapid heartbeat
  • Fever or high body temperature
  • Seizures
  • Hallucinations
  • Loss of coordination
  • Rapid changes in blood pressure


Pro Tip: LSD users may also experience difficulty concentrating and sleeping problems.


Those who are predisposed to psychosis are also at RISK of developing drug-induced psychosis when using LSD. 

This mental health disorder is characterized by delusions, paranoia, and auditory and visual hallucinations that are USUALLY related to drug use.


Are There Positive Long Terms Effects of Acid?

Despite the potential risks of long-term LSD use, some believe that its effects can be BENEFICIAL in certain cases. Research suggests that it could be used to treat a range of conditions and mental DISORDERS, including addiction, depression, bipolar disorder, PTSD, and anxiety.

These studies have shown that using LSD has led to long-term positive changes in mood and attitude, increased creativity, improved sense of well-being, and EVEN reduced stress levels [1].

However, it’s important to note that MORE research is needed before any definite conclusions can be made about the benefits of LSD use.


How to Stay Safe When Taking Acid Long-Term?

It’s important to take precautions when taking LSD. This includes avoiding driving or operating machinery, as the drug IMPAIRS judgment and coordination.

It’s also important to be mindful of your dosage, as higher doses can increase the risk of adverse effects. Start with a LOW dose and gradually work your way up if you want to experiment with stronger doses.


Pro Tip: LSD is not classed as an addictive substance because it does not cause physical dependency. However, it is open to drug abuse as you can build a tolerance to LSD, which could lead to psychological dependency.


Also, make sure to have a sober companion when taking LSD, as the effects can be unpredictable and intense. This way, someone will be there to HELP if something goes wrong.

Ensure you stay safe and DON’T go to new or hazardous locations while under the influence of LSD. Remember to tell your friends or family where you’ll be and when you’ll be back. Ideally, bring someone SOBER with you if you do leave.


Pro Tip: There is no LSD addiction treatment as it is not addictive. However, there is help available for those going through LSD abuse and substance abuse at rehab centers. Stay safe when using psychedelic drugs.


Best Place to Buy LSD Online in Canada

If you want to buy LSD online, we recommend going with our chosen seller. They are reliable and trustworthy, with a great reputation for delivering a PURE product that is free from the risk of tampering. But is tampering REALLY an issue you need to worry about with LSD?

Unfortunately, it is. There are dealers who water down their acid supply with FILLER ingredients that are potentially harmful and could have ADVERSE effects. Some out there are just plain malicious. This is why you have to be careful who you buy LSD from so that you can stay safe.

Enjoy the offerings from our chosen seller and see if they have something right for you.


To Conclude

LSD, or acid, is a powerful hallucinogenic drug that can cause INTENSE visual and auditory hallucinations. It can also produce SIGNIFICANT mood and perception changes in your sense of time and self.

Though it is known to be relatively safe when used responsibly, RISKS are still associated with taking LSD long-term. 

These include HPPD, serotonin syndrome, and drug-induced psychosis. Therefore, it is important to take precautions when using LSD.

Finally, if you are looking to buy LSD online in Canada, make sure you go with a reliable seller who can provide pure products WITHOUT fillers and contaminants. 

Enjoy the offerings from our chosen sellers and see if they have something right for you.



1: Schmid Y, Liechti ME. Long-lasting subjective effects of LSD in normal subjects. Psychopharmacology. 2017;235(2):535-545. doi:10.1007/s00213-017-4733-3

‌2: Goldman S, Galarneau D, Friedman R. New Onset LSD Flashback Syndrome Triggered by the Initiation of SSRIs. The Ochsner journal. 2007;7(1):37-39. Accessed January 2, 2023.

‌3: Singh A, Puskoor S, Saunders R. PROLONGED LYSERGIC ACID DIETHYLMIDE INDUCED SEROTONIN SYNDROME. Chest. 2019;156(4):A2132. doi:10.1016/j.chest.2019.08.2076

‌4: on I. Hallucinogens DrugFacts | National Institute on Drug Abuse. National Institute on Drug Abuse. Published April 22, 2019. Accessed January 2, 2023.

‌5: Liechti ME. Modern Clinical Research on LSD. Neuropsychopharmacology. 2017;42(11):2114-2127. doi:10.1038/npp.2017.86

6: Carhat-Harris, R.L., et al. (2016, February 5). The paradoxical psychological effects of lysergic acid diethylamide (LSD). Psychological Medicine. Cambridge University Press. Available at:


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