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How Long Does LSD Stay In Your System

How Long Does LSD Stay In Your System?

Giordano Novak

Giordano Novak

Medically reviewed by Giordano Novak, University of São Paulo on April 3rd 2022

Key Takeaways:

  • LSD is a powerful hallucinogen that causes significant distortions in perception and cognition.
  • Various factors affect how long LSD stays in the body.
  • Different drug tests can detect LSD for various lengths of time.


Are you curious about how long your psychedelic adventures will stay with you? It’s natural to want to know the answer – after all, there’s no bigger buzzkill than unexpectedly failing a drug test.

Generally speaking, LSD can be detected in the body from two hours to a few days after taking it, depending on the dose taken. 

However, some factors can cause the effects to last longer. It’s also different when your urine is tested as opposed to saliva.

So go ahead–take a hit of knowledge from us as if it were one from Ermintrude, the proto-hippie cow herself. And rest assured: We gotcha covered when it comes to an understanding of exactly how long LSD stays with you.


Definition And History Of LSD

LSD (lysergic acid diethylamide) was a hallucinogenic drug first synthesized in 1938 by Swiss chemist Albert Hofmann [1]

It gained notoriety during the 1960s counterculture movement when it became popular among YOUNG people as a recreational substance.

Its chemical structure is closely related to serotonin, a hormone believed to play an important role in regulating mood and emotion. LSD has been used medically to treat headaches, mental illnesses, and addiction.

LSD can produce powerful PSYCHEDELIC effects on users, including intense visual and auditory hallucinations, altered perception of time and space, and an increased sense of connectedness to others.

Its effects usually last between 6-12 hours after ingestion, although this can vary greatly DEPENDING on dose size and other factors. 

The long-term risks associated with taking LSD are still being studied, but it is generally considered non-addictive and safe when used responsibly.


Understanding The Science Of Acid

The exact mechanism of action for LSD is still not fully understood, but it is believed to work by binding to serotonin receptors in the brain and altering neurotransmitter function. 

These days, it’s classified as a Schedule I substance due to its potential for drug abuse and dependence.


NIH LSD Quote (White)(2)


Here is the process of how LSD works in the body:

The Mechanism Behind Hallucinations

When taken, LSD BINDS to serotonin 5-HT2A receptors, which control cognition, emotion, memory, sleep patterns, and perception of pain and pleasure [2].

These receptor sites become flooded with acid molecules, causing increased electrical activity that can lead to hallucinations and other psychedelic effects.


The Role Of Serotonin

Serotonin also REGULATES our moods, appetite, anxiety levels and how we respond to stress [3]. When LSD binds to serotonin receptors, it increases the amount of serotonin in circulation and can cause changes in our mental state.


The Link Between Dopamine And Acid

In addition to serotonin, some studies have suggested that LSD may also increase DOPAMINE levels. 

This neurotransmitter is associated with the pleasure and reward pathways in the brain, and its release contributes to euphoria when taking psychedelic drugs.


Pro Tip: Try to keep the dose size of LSD as low as possible to reduce your risk of adverse effects.


How Many Days Does LSD Remain In Your Body?

LSD is considered to have a relatively SHORT elimination time from the body, from two hours to a few days. 

The effects of acid may also last longer than expected due to cross-tolerance, where taking one substance increases your tolerance for another similar substance.

If you are being tested in a lab, they will likely look for LSD metabolites in your urine sample. These metabolites remain in the body much LONGER than the actual drug and can linger in urine samples for up to 12 days after ingestion.

Depending on how the test is conducted and which type of sample is taken (urine, blood or saliva), LSD can be detected in those samples for up to one week after ingestion.


Pro Tip: When using psychedelics like LSD, always practice moderation and respect your body’s limits.


Factors That Affect The Length Of Stay Of Acid In Your Body

The length of time that LSD remains in the body varies from person to person and is influenced by a number of different factors. Some of these factors include:



Metabolism refers to the rate at which our bodies process certain drugs and substances. Those with a quicker metabolism will have SHORTER LSD detection times than those with slower metabolisms.


Frequency of Use

Frequency of use is another factor influencing the length of time LSD remains in the body. If an individual consumes LSD regularly or in large doses, it can stay in their system for MORE extended periods of time.

Long-term users may also develop a tolerance to the drug, making it challenging to detect levels of LSD in laboratory tests accurately. When using psychedelics like LSD, moderation and respect for your body’s limits are critical.



The dosage of LSD is essential in determining the length of time it will remain in the body. 

A HIGHER dose of acid may have a long elimination time than a lower dose, as more molecules are being processed by our systems and take longer to clear out the body.

Additionally, suppose someone takes multiple doses of LSD at once or over a short period. In that case, it can cause an accumulation effect and increase their chances of having the drug detected in laboratory tests.


Drug Interactions

Furthermore, drug interactions can also affect the length of time LSD remains in the body. If someone is taking medications or other drugs, these can interfere with how acid molecules are processed and may lead to longer detection times in laboratory tests.

For this reason, it is important to be MINDFUL of any potential drug interactions when taking psychedelics like LSD. 

It’s also a good idea to talk to your doctor if you are considering using LSD so that they can provide advice on dosage, frequency of use and any possible drug interactions.


Body Mass Index (BMI)

The body mass index (BMI) can also influence how long LSD remains in the body. 

Those with higher BMIs may have LONGER detection times than those with lower BMIs, as more fat and muscle tissue are available to store psychedelics like acid molecules.



Age can also affect the length of time acid remains in the body. Generally, YOUNGER individuals have faster metabolisms and may process drugs like LSD more quickly than older individuals.

In addition to age, lifestyle factors such as diet, exercise habits, sleep patterns and hydration levels can influence how quickly our bodies process substances. 

Therefore it is important to lead a healthy lifestyle if you are planning on consuming psychedelics like LSD.


Hydration Levels

Being ADEQUATELY hydrated helps to speed up metabolic processes, which in turn helps our bodies to process and eliminate substances like LSD more quickly.

Dehydration caused by alcohol or drug use can increase the elimination rate of psychedelics like LSD as well, so it is important to stay hydrated if you are using these substances.


Genetic Variations

Genetic variations can also affect the length of time LSD remains in your body. Variations in certain metabolic ENZYMES, such as those that break down and metabolize drugs like LSD, can cause changes in their elimination rates.

This means that some individuals can process substances like acid more quickly than others, leading to shorter detection times for laboratory tests. 

Additionally, hereditary factors which affect metabolic processes may influence how long LSD stays in the body.


Liver Functioning

The functioning of the liver can also influence how long LSD remains in the body. If your liver is not functioning OPTIMALLY, it may take longer to process and eliminate acid molecules from your system, leading to longer detection times for laboratory tests.


Exercise Habits

Finally, regular exercise can help to SPEED up metabolic processes and drug elimination rates. 

Exercising regularly can also help to improve your overall physical health, which helps to support the functioning of the liver and other organs responsible for eliminating drugs from our bodies.


Pro Tip: If you’re going to be taking LSD frequently, make sure that you are leading a healthy lifestyle with plenty of exercise and hydration.


Is It Possible To Detoxify Your Body Quicker?

While there is no way to detoxify your body from LSD in a shorter time completely, some STRATEGIES may help speed up the process. For one, exercise can help boost your metabolism and elimination rate, as mentioned.

Additionally, drinking lots of water and avoiding alcohol consumption can help flush out any remnants of acid molecules from your body more quickly. 

Another way to potentially reduce the detection times for laboratory tests is by taking certain supplements or herbs.

Milk thistle has been known to support liver HEALTH, while other herbs such as dandelion, valerian, and chamomile have been shown to help eliminate toxins from our bodies.

However, it is important to note that these supplements and herbs should only be used in MODERATION, as over-consumption could lead to adverse effects.


Best Place to Buy LSD Online in Canada

If you’re looking to buy LSD online in Canada, it is important to make sure you are using a trusted and reputable vendor. 

Most vendors offer secure payment methods, discreet shipping options, and quality assurance measures to ensure your purchase is safe and reliable.

Be sure to research any potential vendor thoroughly before making a purchase. Additionally, check local laws in your area, as some regions may restrict buying or possessing psychedelics like LSD.



LSD has a relatively short-lived presence in the body, typically lasting anywhere from a couple of hours to several days. However, some factors can influence how quickly our bodies process and eliminate substances like LSD.

Drinking plenty of water, exercising regularly, avoiding alcohol consumption and taking certain supplements or herbs may help speed up metabolic processes for quicker elimination of LSD molecules from our bodies.

By following these tips and leading a healthy lifestyle overall, you can ensure that your experience with psychedelics is safe and enjoyable.


  1. Editors. LSD. HISTORY. Published June 14, 2017. Accessed January 4, 2023.
  2. Nichols DE. Psychedelics. Barker EL, ed. Pharmacological Reviews. 2016;68(2):264-355. doi:10.1124/pr.115.011478
  3. Scaccia A. Everything You Need to Know About Serotonin. Healthline. Published September 26, 2022. Accessed January 4, 2023.
  4. NCBI – WWW Error Blocked Diagnostic. (n.d.-b).



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