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Improving your mood with low doses of LSD

Improving Your Mood With Low Doses of LSD

Giordano Novak

Giordano Novak

Medically reviewed by Giordano Novak, University of São Paulo on April 3rd 2022

The classic serotonergic psychedelic lysergic acid diethylamide (LSD) was widely studied in humans from the 1950’s to 1970’s. Today, LSD is again the focus of clinical exploration, including experimental studies in healthy subjects, exploring the potential for mood enhancement and the long-lasting impacts of the use of these substances. In researching the relationship between LSD and mood, LSD was found to have increased optimism and trait opennesseven after up to two weeks post “trip”.  Clinical studies have demonstrated “acute changes in waking consciousness”; such as increased blissful state and

insightfulnessand enhanced mental well-being after a single full psychedelic dose of LSD (100mcg LSD tabs to 200 mcg LSD tabs) in healthy volunteer subjects. 


In recent years, there has been a growing popular interest in microdosing with psychedelics such as LSD for the improvement of mood. A microdose is suggested to be “one-tenth of a regular consumed dose; small enough not to disturb daily life activities, but large enough to enhance cognitive or emotional processes and wellbeing.”  The results of this research suggested that this practice of using one-tenth of a full psychedelic dose while adhering to a specific dosing schedule, serves to enhance mood and performance. Nonetheless, controlled research on the efficacy of microdosing is scarce and deeper examination is required to determine cause and effect results. 


The main objective of this dose-finding was to determine the minimal dose of LSD needed to affect mood and cognition. This study was conducted to assess the acute effects of three LSD doses (5, 10, and 20 mcg) on measures of cognition, mood, and subjective experience observing effects up to 6 hours after the administration of the substance. LSD showed positive effects in the majority of observations by increasing positive mood (at a dose of 20 mcg), friendliness (5 and 20 mcg), arousal (5 mcg LSD), and decreasing attentional lapses (5 and 20 mcg). Some negative effects were also noted with these low doses, such as confusion and anxiety – highlighting the importance of knowledge of and preparedness in set and setting; and speaking to the individual variation of the effects of low doses of LSD on cognition. In accordance with anecdotal reports, low doses of LSD can enhance attention in the majority of research observations. Overall conclusions from this study demonstrate “selective, beneficial effects of low doses of LSD on mood and cognition in the majority of observations.”

Future studies on microdosing LSD for mood and cognition are absolutely required in order to bring validity to the potential of integrating these substances into clinical and mental health settings for therapeutic use. And be sure to buy LSD online in Canada from a trusted source for reliable and optimal results.



Carhat-Harris, R.L., et al. (2016, February 5). The paradoxical psychological effects of lysergic acid diethylamide (LSD). Psychological Medicine. Cambridge University Press. Available at:

Liechti, M.E., Dolder, P.C. & Schmid, Y. Alterations of consciousness and mystical-type experiences after acute LSD in humans. Psychopharmacology 234, 1499–1510 (2017). Available at:

Science Direct. (2022). Drug Microdose. Available at:

Hutten, N., et al. (2020, December). Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study. Available at:

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